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Studies on mice demonstrated that administration of exendin-4 ( ip ) prior to cognitive tests enhanced performance during difficult probe tests but only in females [50]

10.1194/jlr.M077313 J Lipid Res

There were signs of this in the form of reduced levels of glycosylated hemoglobin and systemic inflammatory symptoms (Yao et al., 2013)

28 At the cellular level, NTBI, which is accepted as the unstable iron pool, is composed of ferrous iron bound by low-affinity iron chelators

While these studies do not directly target the knee joint, they substantiate the core principles required for intra-articular therapy: 1) precise delivery of energy to a defined deep target, 2) the ability to trigger relevant biological responses (anti-inflammatory or neuromodulatory), and 3) a viable clinical safety profile