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Unlike thiazolidinediones (such as pioglitazone), which activate peroxisome proliferator-activated receptors and directly promote sodium and water retention, tirzepatide's receptor targets do not have this established effect

Currently, some countries are considering to ban it entirely (like Denmark) and the permitted use level is very low (under 0.01%)

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Meanwhile, a process called adaptive thermogenesis kicks in, where your body becomes slightly more efficient at using calories, burning fewer than predicted by weight alone