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Serum GLP-1 levels showed direct proportionality with several metabolic risk markers (that is, body mass index (BMI), leptin, insulin) over 109 men diagnosed with schizophrenia and on clozapine, while this association was not observed in women 131

Figure 1 Figure 2 The discovery of the second incretin, GLP-1, originated from observations in 1982 that anglerfish proglucagon mRNA contained coding sequences of glucagon-related peptide, flanked by pairs of basic amino acids characteristic of the sites cleaved during post-translational processing of prohormones ( Figure 1 Section A]

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MD simulations were performed using the GROMACS 2018 package 41 with isothermalisobaric (NPT) ensemble and periodic boundary condition