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Modulating ion channel activity provides a powerful means of influencing neuronal behavior, offering potential therapeutic avenues for a wide range of neurological and psychiatric disorders ( Ca 2 + ions serve as vital second messengers, regulating key cellular processes such as neurotransmitter release and gene expression (Pikor et al., 2024)

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Neurological manifestations include developmental delay, psychomotor retardation, behavioral abnormalities, ataxia, peripheral neuropathy, and seizures