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This observation indicates that ADH5 is epistatic to GCLM in the FA viability assay performed in HCT116 cells, although this phenotype might also be a consequence of partial GSH depletion in GCLM cells compared to the full GSH depletion achieved by L-BSO (Supplementary Fig

10.1038/srep17316 92 LangE.ZelenakC.EberhardM.BissingerR.RotteA.GhashghaeiniaM.et al (2015b)

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It is important to recognise that fatigue is a non-specific symptom with multiple potential causes

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