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Indeed, it is lack of antagonism and not necessarily synergy that should be the final goal of combinations, since synergy is not required for successful combination treatments in patients 86,87

10.1001/jama.1958.02990240001001 344 WilkinsR

this is not an overnight transformation, but the cumulative effect over several months is significant for many patients

Effectiveness of cognitive behaviouralbased interventions for adults with attentiondeficit/hyperactivity disorder extends beyond core symptoms: A metaanalysis of randomized controlled trials

Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems

PubChem (s.f.)