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However, these synthetic versions are engineered to resist breakdown by the DPP-4 enzyme that rapidly degrades natural GLP-1, remain active in the bloodstream for much longer periods (days to weeks versus minutes for natural GLP-1), and achieve blood concentrations far higher than the body naturally produces

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The two values are comparable both from low-receptor-density cAMP assays (Coskun 2022 explicitly used Willard 2020's method), with a small cross-lab offset (~1.2, gauged from native-ligand controls) so treat the ~16 as a ratio rather than an exact multiple

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