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Conclusions Our study identified genetic proxies of GLP-1R-based agonists and demonstrated their causal effects on reducing the risk of MASLD and complications including liver cancer and CVD, probably by improving hyperlipidemia and insulin resistance and partly independent of the weight-loss effect
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It has shown strong Phase III clinical results and represents a new generation of obesity therapies with improved efficacy and metabolic benefits
However, like all medications, they can produce side effects that may affect the cardiovascular system in certain individuals
Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial
