B12 is one of the nutrients I pay particular attention to because the consequences of untreated deficiency are significant, but it never sits in isolation in the patients I see
By inhibiting NNMT, 5-Amino-1MQ effectively disrupts this process, leading to a reduction in fat storage and promoting increased fat oxidation
Dont picture a steady, predictable decline, though
Therefore, serum potassium levels and the platelet count should be monitored carefully during therapy
Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations
however, the only statistically significant difference was between the LD control group and both groups switched from WD to LD, regardless of their treatment (Supplementary Fig