4-octyl itaconate and dimethyl fumarate induce secretion of the anti-inflammatory protein annexin A1 via NRF2
Abbreviations AIH: Alcohol-induced hyperlipidemia CM: Cordyceps militaris CM: Cordycepin-rich CM GSH: Glutathione HDL: High-density lipoprotein OS: Oxidative stress PJ: Paecilomyces japonica SD: SpragueDawley SM: Silymarin TBARS: Thiobarbituric acid-reactive substances TC: Total cholesterol TG: Triglyceride References AlHajri L, AlHadhrami A, AlMheiri S, AlMutawa Y, AlHashimi Z (2017) The efficacy of evolocumab in the management of hyperlipidemia: a systematic review
ROS are molecular by-products of metabolized cells
These may signal that the medication is affecting the gastrointestinal system more than expected
Figure 1: Top 10 medicines associated with gynaecomastia in the CARM database (number of reports) Management If medicine-induced gynaecomastia is suspected, the medicine should be withdrawn or discontinued if possible 2,4
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