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To confirm the phenotype changes were driven by OGDHc inhibition, we also treated cells with DM-2OG, mimicking impaired 2-OG metabolism by the OGDHc, and found that, similarly to ML226, DM-2OG increased the CCR7 high CD45RO high population, with a corresponding decrease in the CCR7 low CD45RO high population (Fig

Here we uncover ABHD11 as a noncanonical deglutarylating enzyme critical for maintaining the tricarboxylic acid (TCA) cycle

11, June 2011, pp

Carotid artery ultrasound and echocardiography testing to lower the prevalence of Alzheimers disease

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