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In knock-out mice, the loss of the KHK gene is associated with a reduced desire for ethanol intake

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In skeletal muscle, increased TGF-1 contributes to impaired exercise response by suppressing key mitochondrial regulators, such as PGC1 and AMPK2 (Bohm et al

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However, at 12 months post-index, 13.6% and 9.0% of patients in cohorts 1 and 2, respectively, were receiving the 3.0-mg dose