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Major barriers to clinical application include limited BBB penetration, subtype heterogeneity and long-term safety of cell-based approaches

In particular, aerobic respiration by mitochondria (the powerhouses of the cell) leads to the production of ROS as oxygen is gradually converted into water

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Chronic kidney disease in heart failure with preserved ejection fraction In the pooled analysis of the SUSTAIN 6 and LEADER trials, with median follow-up periods of 2.1 and 3.8 years respectively, semaglutide and liraglutide demonstrated significant renal benefits compared to placebo