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People not generally eligible for GLP-1s at higher doses

The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

* Abraham NS, Barkun AN, Sauer BG, et al

People on metformin, sulfonylureas, or insulin should treat this the same way theyd treat starting any new supplement, get clearance first

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