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Patients often notice: Reduced food obsession Less binge eating Better control around sweets 5

The hexosamine pathway is activated by high blood sugar levels, which causes damage to Schwann cells and nerve cells through inflammation and oxidative stress, eventually leading to diabetic peripheral neuropathy (DPN)

However, the Clinical Study of Obesity and Intestinal Microbiota (ECOMI) trial showed that short-term CR (12 weeks) can lead to significant improvements in anxiety and depression scores in obese individuals only when combined with probiotic supplementation (63)

Most Medicare plans do not cover weight loss medications, unless the drug is approved for another condition, like diabetes

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Monitoring during transition Weigh yourself under consistent conditions (same time, same clothing) throughout the transition