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doi: 10.1371/journal.ppat.1000586 7 AndaloroC.SantagatiM.StefaniS.La MantiaI

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

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Reduced IDO1 is associated with the progression of colonic inflammation in mice, and supplementation with tryptophan (Trp) or an AhR agonist can ameliorate intestinal inflammation, suggesting that this pathway may have important clinical value in the treatment of IBD (94, 95)