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Additionally, indole-3-carboxylic acid (ICA), a metabolite derived from Lactobacillus gallinarum , has been shown to improve anti-PD-1 efficacy in mouse models with different microsatellite instability (MSI) statuses [104]

Cell proliferation was evaluated using a Promega CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) as per the manufacturers instructions (Promega G3580)

Its a resounding yes

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Of greatest concern with overdosage or chronic overuse would be copper toxicity

These insights open new avenues for research into pathogenesis and the investigation of targeted approaches based on the modulation of proteasomal function