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Notably, some studies have used spatial transcriptomics to reveal that antidepressant Chinese medicines exert their effects by modulating genes involved in neuroinflammation and neuroplasticity [539]
To address this, advanced modeling strategies based on human single-cell and spatial transcriptomics are neededsuch as human skin organoids, ex vivo skin explants, or fully immunocompetent humanized mouse modelsto dissect the true functional landscape of Vitamin D within complex signaling networks
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