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PMID: 23684623

Both compounds are developed by Eli Lilly, both target GLP-1 and GIP receptors, but Retatrutide adds a third receptor glucagon creating a triple agonist with superior weight loss results in clinical trials

PMID:1658407 [5] Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME

Cell Death Differ (2022) 29(9):1790803

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This interspecies variability, particularly among ants, bees, and humans, suggests that the PAS position may contribute to differential ligand recognition and should be considered in the design of insect-selective AChE inhibitors ( Table 5 )