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However, the miR-21 expression by the influence of curcumin is downregulated in hepatocellular cancer cells, which stimulates the expression of metalloproteinase-3 (TIMP3) and suppresses the GF-b1/smad3 signalling, resulting in the proliferating of cancer cells (Li et al., 2020)

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Moreover, the formulation exhibited excellent structural integrity and drug-loading stability under various pH conditions that simulate the gastrointestinal environment, particularly under harsh acidic conditions