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Most recently, in a new structure of GLP-1R, a small molecule agonist, TT-OAD2, was shown to activate the receptor through binding of the helix IIECL1helix III region, revealing another ECD conformation 25

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To answer this, its important to separate short-term effects from long-term outcomes

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Despite scarce data on GLP-1 distribution for Ozempic and Wegovy, studies report low patient adherence, as those still using the drugs drop to less than a third (32%) after the first year, then to 15% after year two