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It is better to take a standard serving every day than to double up once a week

While some individuals may experience symptoms for a few weeks or months, others may struggle with persistent symptoms for years

Additionally, avoid the use of mixed agonist/antagonist (e.g., pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including hydrocodone bitartrate and acetaminophen tablets

Injection site reactions occurred in a small percentage of participants

Science 368:945946