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Mirtazapine: a review of its use in major depression and other psychiatric disorders

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This takes place after the transduction of the messenger RNA (mRNA) from NRF-2, binding a homodimer of KEAP1, and afterward, binding with a full dimer, resulting in the degradation of NRF-2 by the previously mentioned Neh [21]

Hormonal dysfunction of visceral adipose tissue causes changes in the adipokine secretion profile, which leads to further disturbances of the HPO axis function