Inhibition of Glucagon Secretion : It decreases glucagon secretion from pancreatic alpha cells, which lowers hepatic glucose production
CrossRef Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases Maite Martnez-Ua, Yaiza Lpez-Mancheo, Carlos Diguez, Manuel A
Beneficial effects on RBCs also were shown
Clinical Trial Results STEP Trials (Semaglutide) The STEP program studied semaglutide 2.4 mg weekly in overweight/obese adults: STEP 1 : 16.9% average weight loss over 68 weeks vs 2.4% placebo STEP 2 (T2D patients): 9.6% weight loss STEP 3 (with behavioral therapy): 16.0% weight loss STEP 5 (2-year data): 15.2% sustained weight loss SURMOUNT Trials (Tirzepatide) The SURMOUNT program studied tirzepatide at 5mg, 10mg, and 15mg weekly: SURMOUNT-1 : 20.9% average weight loss at 15mg over 72 weeks vs 3.1% placebo SURMOUNT-2 (T2D patients): 14.7% at 15mg SURMOUNT-3 (with lifestyle intervention): 26.6% at highest dose SURMOUNT-4 (maintenance): continued weight loss vs weight regain on placebo Head-to-Head No large head-to-head trial has directly compared them at optimal doses for weight loss
Li J, Liu J, Xu Y, Wu R, Chen X, Song X, et al.Tumor heterogeneity in autophagy-dependent ferroptosis
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