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The cavity in the center of the crown ether molecule is lined with oxygen atoms and is large enough to be occupied by a cation, such as K +

It also inhibits kidney fibrosis in unilateral ureteral obstruction rats by downregulating the wingless-type MMTV integration site family (Wnt)/-catenin signaling pathway, significantly reducing the expression of Collagen I, Vimentin, and alpha-smooth muscle actin (-SMA), while enhancing E-cadherin expression (Ruan, 2020)

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Activation of these proteins contributes to actin cytoskeleton remodeling and changes in cell migration behavior