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PLoS ONE 12 , e172233 (2017)

The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

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L-carnitine supplementation in heart failure patients with preserved ejection fraction

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Further, semaglutide stimulated the anti-inflammatory markers of M2 microglia subset and the cAMP/PKA/p38 pathway, which in turn stimulated the expression of cell-specific anti-inflammatory factors, interleukin-10 and IL-4 (Tamayo-Trujillo et al