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This led researchers to wonder if GIP agonists would even work in the population that needed them most
12 Neurobiological changes are evident in the premonitory stage and include alterations in nociceptive signalling, while the headache phase involves activation of the trigeminovascular system and, in migraine with aura, a cortical spreading depression-like event characterised by an electrophysiological wave of excitation followed by inhibition in cortical neurons
Anything that disrupts this process, including alcohol, can reduce the effectiveness of treatment
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