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Peters EM, Arck PC, Paus R

10 To test whether the induction of p70S6K1 phosphorylation is due to inhibition of IGF-1R signaling pathway not non-specific outcome of OSI-906, the HCT116 cells were treated with other IGF-1R inhibitors, BMS-754807 and GSK1838705A, for 072 h

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However, it does not affect the progression of the disease in the advanced stages, benefiting only around 5% of ALS patients, and for this reason, in Europe, this drug has been withdrawn from the marketing authorization process [78]

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