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None of the tested treatments, including GLP-1MK-801, triggered pica behaviour in Wistar rats, indicated by the low consumption of the non-nutritive substance kaolin (Extended Data Fig

Retatrutide activates GLP-1, GIP, and glucagon receptor pathways

Mechanism Comparison Semaglutide activates the GLP-1 receptor alone [4]

This approach preserves approximately 75% of the appetite suppression effect through sustained GLP-1 and GIP activation

34 These effects are achieved by the expression and translocation of apical glucose transporter type 4 (GLUT4) thus increasing glucose uptake and by the inhibition of pro-apoptotic proteins such as Bad, Bax and FOXO family proteins, thereby improving beta cell survival