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Apart from intrinsic signaling, the TME shapes CSCs behavior and mechanical cures from ECM further modulates CSC fate, with poor stiffness enhancing stemness and high stress leading to quiescence via distinct integrin-dependent pathways

Additionally, the final follow-up indicated no significant variation in the rates of excellent and good outcomes, suggesting that the initial therapeutic advantage conferred by dexamethasone and VB12 did not translate into superior long-term outcomes

Another study demonstrated that liraglutide alleviated CM-associated hyperalgesia by inhibiting CGRP, phosphorylated ERK ( p -ERK), and c-fos protein levels in the TNC, with a concurrent increase in IL-10 release [95] (Fig

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