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Comparison of upper extremity lymphedema after sentinel lymph node biopsy and axillary lymph node dissection: patient-reported outcomes in 3044 patients

In the HIACE RCT, Tse et al

Metformin typically lowers A1C by about 1% to 1.5%

However, a negative result for those antibodies is of limited value, since some patients with PA lack the antibodies

Important safety considerations include: Gastrointestinal symptoms at higher doses Individual tolerance variability Potential for hypoglycaemia when combined with insulin or sulphonylureas Limited long-term safety data in humans Limited data in children and adolescents Patients with diabetes taking glucose-lowering medications should exercise caution when introducing allulose