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Under normal physiological conditions, uptake of oxLDL by macrophages is probably generally protective, because subsequent efflux of the cholesterol from the macrophages to HDL via reverse cholesterol transport as well as emigration of these macrophages from the arterial wall to lymph nodes serves to minimize the accumulation of cholesterol-laden macrophages in the arterial wall

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When freeze-drying is performed without a protective matrix (such as sucrose or mannitol), residual bound water may cause collapse during the final drying stage

Untreated vitamin B12 deficiency may contribute to long-term neurological complications over time

As of 2025, no large-scale human RCTs on BPC-157 for musculoskeletal repair had been published

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