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Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans
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doi: 10.1073/pnas.1906908116 Summary Keywords cognitive function, neuroinflammation, oxidativestress, plant-based nutrition, thyroidbrain axis Citation Zhang Z, Xu M-X, Wang N, Shen R, Sun J, Zha M and Wang M (2026) Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances
Efficacy In the original phase 3 randomized trials for obesity, average weight reduction compared to placebo has ranged from 5.3% to 17.8% after 56 to 72 weeks (Table 1), with improvements in several obesityrelated risks and complications [13, 14, 15]
The primary end points of this study, which involve monitoring the incidence of treatment-emergent adverse events, are suitable for the objectives of a Phase 1 trial
