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The exact mechanism linking GLP-1 receptor agonists to ischemic optic neuropathy and retinopathy remains unclear, but several hypotheses exist: Vascular Changes: GLP-1 drugs influence blood vessel function and may inadvertently contribute to changes in retinal microcirculation

Tatsuo Y, Natsuko NT, Tanemichi C

Patients with type 2 diabetes should be monitored closely, especially for changes in vision or worsening eye disease

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We extracted GLP-1 RAs (exenatide, liraglutide, dulaglutide, lixisenatide, semaglutide, tirzepatide) and DPP-4 inhibitors (linagliptin, alogliptin, saxagliptin, sitagliptin) from Q1 2013 to Q1 2024 for all AEs classified as biliary disorders (SMQ), with the drug role selecting the primary suspect drug (PS)