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If you reach day 14 without any perceived benefit at your starting dose, a modest increase to 0.2 mg may be warranted

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Patients with unstable cardiovascular disease, poorly controlled hypertension, or significant hypotension may require additional monitoring or alternative therapies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Frandsen C.S., Dejgaard T.F., Holst J.J., Andersen H.U., Thorsteinsson B., Madsbad S