By participating in NLRP3 and NF-kB related signalling pathways, empagliflozin, a new hypoglycaemic drug that can improve the prognosis of CVDs, can attenuate ferroptosis, fibrosis, apoptosis, and inflammation in doxorubicin-treated mice and significantly improve cardiac function, thereby opening up a new avenue for the treatment of doxorubicin-related cardiotoxicity [150, 151]
Unfortunately, glutathione levels decrease with age, stress, lack of proper diet, exposure to toxins, and diseases such as diabetes
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Importantly, PRMT1-mediated arginine methylation within the C-terminal RGG motif (R272/278/280/282/345) enhances AUF1 p45 activity, enabling methylated AUF1 p45 to exhibit a higher RNA-binding affinity and more effectively stimulate viral RNA synthesis [164]
