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This supports the conclusion of neutral or slightly reduced risk of fracture with GLP-1 RA treatment compared to DPP-4i treatment in this population

This distinction is central to interpreting the available evidence

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The Key Factors in the Methylation Cycle We will now consider three important causes of interruption to the methylation cycle: Vitamin B12 deficiency Folate deficiency MTHFR mutation Vitamin B12 deficiency If vitamin B12 is deficient, the methyl group cannot be transferred from methylfolate to the methionine cycle