The one supplement to use with caution is iodine, which makes the thyroid work more efficiently and make more thyroid hormones
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When there are sufficient grounds to suspect G6PD, a direct test for G6PD is the "Beutler fluorescent spot test", which has largely replaced an older test (the Motulsky dye-decolouration test)
If it is as high as 18 umol/L, there are likely two MTHFR mutations
if youre still uncomfortable, its common to hold longer before moving up
The peptide purity and COA interpretation guide covers what researchers should verify in vendor documentation