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Older oral agents such as phentermine-topiramate extended release, naltrexone-bupropion and orlistat cost considerably less

As alluded to above, the rationale for combining GLP-1R agonism with either GIPR agonism or antagonism is, however, still debated, and how the GIPR agonistic properties of tirzepatide contribute to body-weight loss remains unclear [19]

Advances in GLP-1 therapies have transformed our medical approach to obesity a condition that impacts heart health, metabolic risk, and overall well-being