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After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency

Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]

Hot flashes, night sweats, and sleep loss often coincide with these swings, not with stable low estrogen

Its benefits include: Tendon and ligament injuries helps collagen production and improves blood flow for faster healing

Much of the evidence comes from laboratory and animal studies, so benefits in humans are not guaranteed