In head-to-head trials, metformin has been shown to produce equivalent reductions in A1c as sulfonylureas and thiazolidinediones but is more potent than DPP-4 inhibitors (53)
Humana Press: Totowa, NJ, 1997

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Its reduced levels in obesity, type-two diabetes and atherosclerosis likely result from inflammation, adipose tissue hypertrophy, and oxidative stress 38
Such differences in compliance between GLP-1RA preparations are mainly due to the differences between injection devices [172]
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