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Serum was obtained by centrifugation for 10 min at 2000 RPM g and 4 C (Heraeus Multifuge 3 S-R, Fa

It was first used to describe a cell death process induced by a small molecule called erastin, which inhibits the intake of cystine, resulting in glutathione depletion and inactivation of the phospholipid potentially toxic lipid peroxidase 4 (GPX4) (Yang et al., 2014)

doi: 10.1007/s00401-015-1502-4

In the first two studies, changes in redox and methylation metabolism were reported but because the studies were open-label the changes in these biomarkers were not compared to a placebo group

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If nausea persists after restarting tirzepatide, contact your PlexusDx providerthey may recommend staying on a lower dose for one additional week before titrating up, or suggest ginger tea and small, frequent meals to manage symptoms