Lack of dosing safety studies: Even small differences in dose may lead to drastically different outcomes due to its extreme potency
The SURMOUNT-1 Phase 3 trial published in The New England Journal of Medicine enrolled 2,539 adults with obesity and demonstrated mean body weight reduction of 20.9% at 72 weeks on tirzepatide 15mg weekly versus 3.1% placebo
Leptin is not only secreted in the placenta and adipose tissue, but also in the gut
Alzheimers Disease More clinical studies are still needed, but so far animal and lab studies are pointing toward carnosines ability to decrease the buildup of amyloid beta, which is the main component of the plaque found in the brains of Alzheimer patients
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