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Things do get better after that, but it is a slow process and an uphill journey

326 These resistance traits are a significant barrier to treatment success, contributing to tumor recurrence and metastasis even after initially effective interventions

The role of Drp1 in mitochondrial fission after APAP overdose was subsequently confirmed by other studies [74], suggesting that alterations in mitochondrial dynamics after APAP overdose could have important mechanistic implications

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Am J Pathology 175:225234