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856 Neurodegenerative diseases involve decreased GLUT1 and GLUT3, impairing glucose metabolism

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This balance ensures they may continue functioning for their expected lifespan of dozens of charge cycles

Research from the Journal of Clinical Investigation shows tirzepatide binds the GIP receptor with affinity similar to native GIP (Ki of 0.135), while its GLP-1 receptor affinity is roughly five-fold weaker than native GLP-1 (Ki of 4.23)