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When the middleman gets removed, the drug does not change

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For the purposes of energy and muscle metabolism, GLP-1 does three things that matter enormously as we age: Blood Sugar Control GLP-1 signals the pancreas to release insulin only when glucose is actually present preventing the spikes and crashes that drain energy and damage muscle tissue over time Heart & Vessel Protection GLP-1 receptors in the heart and blood vessels reduce inflammation and support healthy circulation the same mechanism that made GLP-1 drugs compelling in cardiovascular trials Appetite & Brain Signaling GLP-1 crosses the blood-brain barrier and activates satiety centers reducing hunger without the jitteriness of stimulants, creating a calmer, more stable energy state The challenge is that GLP-1 has an extremely short life in the body naturally degraded by an enzyme called DPP-4 within about two minutes of release

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Metabolism 21 (3), 611621