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It activates protein phosphatase 2A, which removes the regulating phosphate group from the liver bifunctional enzyme, the inactivating phosphate from pyruvate kinase, and an inactivating phosphate group from a transcription factor, ChREBP (Carbohydrate Response Element Binding Protein) that activates transcription of genes for fatty acid synthesis in the liver

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661 These molecules function by inhibiting the PI3K/Akt signaling pathway and activating mitochondrial apoptotic pathways

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As GHK-Cu is a copper complex, avoid combining the reconstituted solution with strong chelators or high concentrations of reducing agents

10.1021/bc00025a010 108 SikiricP.DrmicD.SeverM.KlicekR.BlagaicA