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Pilots whose diabetes is controlled through diet, lifestyle interventions or remission may be eligible for immediate issuance by their Aviation Medical Examiner (AME) if they do not have disqualifying cardiovascular, neurological, renal or ophthalmological complications

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331,332 As a bridge of intercellular communication, classical exosomes have a monolayer structure, which can encapsulate bioactive substances, such as proteins, lipids, DNA, and RNA, in the core and deliver them to effector cells to play specific biological functions (Fig