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Discussion We demonstrated in the first part of the present work that both glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS) have potent redox characteristics that prevent nitration of Y198 and Y250 of the HGF -chain, thereby preserving the ability of HGF to bind to the receptor c-met and hence activate myogenic stem satellite cells in vitro (Figure 1b-d, and Figure 1e left column)

Based on early human studies and animal research, GLP-1 agonists may affect: Reward-related eating behaviours by potentially modulating dopamine signalling in brain reward circuits Food cravings and hedonic eating (eating for pleasure rather than hunger) Impulsivity around food , possibly reducing the compulsive aspects of eating Satiety signalling , enhancing the feeling of fullness after meals Some patients using GLP-1 medications for diabetes or weight management report not just reduced appetite but also diminished preoccupation with food, fewer intrusive thoughts about eating, and reduced cravings for specific foods, particularly those high in fat and sugar

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