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For some patients, prednisone's appetite effect completely overrides semaglutide's suppressant action, making weight loss nearly impossible during high-dose corticosteroid therapy

Specifically, the ELIXA (lixisenatide) trial studied patients with T2DM who had recent acute coronary syndrome and found that the addition of lixisenatide to conventional therapy did not result in a significant difference in cardiovascular endpoints relative to placebo (Table 1) [56]

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Insert the needle at a 45-90 degree angle depending on how much subcutaneous fat exists at the site